In order to get the very best prints from your 3D printer, you have to calibrate Slic3r to your specific printer. Each 3D printer brand will have its own calibration settings; even printers in the same brand will have differences. If you have built your own 3D printer, great! But it's even more important for us to calibrate Slic3r to your printer to get the very best prints out of it.
The first thing we need to make sure is that the printer, which we will be calibrating, is set up properly and will be able to produce a good print on its own. What this means is that we need to make sure of the following: