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Introduction to Mathematical Oncology by Steffen E. Eikenberry, John D. Nagy, Yang Kuang

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Chapter 5

Prostate Cancer: PSA, AR, and ADT Dynamics

5.1 Introduction

The prostate is a walnut-shaped and sized organ that envelops the urethra. Accounting for at most 0.1% (and as little as 0.01%, depending upon the individual) of the male body mass, it remains something of a mystery why neoplasms of this tiny organ contribute so greatly to cancer burden. Prostate cancer (PC) accounts for 25% of new cancer diagnoses and 10% of cancer deaths in American men [28].

Prostate cancer incidence and mortality vary widely worldwide, with those in the West far more likely to die of the disease. The natural history of prostate cancer spans decades, and can begin in the third or fourth decade of life, as shown by autopsies of men who died of other causes. ...

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