Chronic pain is a major cause of functional impairment and disability and is frequently associated with psychopathology. Chronic pain can adversely affect a person’s psychological state, and psychopathology can influence the perception and meaning of pain. There is a complicated interaction between somatic and psychological mechanisms in chronic pain that must be sorted out and both must be addressed in treatment. Chronic pain is by definition a chronic persistent illness and requires a multidisciplinary approach to treatment. The focus of this chapter is on psychopharmacological treatment.

Pain is divided into two categories: neuropathic and nonneuropathic. Neuropathic pain results from a neural injury or ...

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