Chapter 1

Mechanisms of Gene Regulation: Boolean Network Models of the Lactose Operon in Escherichia coli

Raina Robeva*, Bessie Kirkwood* and Robin Davies, *Department of Mathematical Sciences, Sweet Briar College, Sweet Briar, VA, USA, Department of Biology, Sweet Briar College, Sweet Briar, VA, USA

1.1 Introduction

Understanding the mechanisms of gene expression is critically important for understanding the regulation of cellular behavior. Transcription of genes (messenger RNA (mRNA) synthesis), translation of mRNA (protein synthesis), degradation of mRNA and proteins, and protein–protein interactions are all involved in the control of gene expression where proteins may bind with DNA, with mRNA, and with other proteins, leading to complex ...

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