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Metabolomics and nutritional challenge tests

what can we learn?

L. Brennan1,2    1 University College Dublin, Dublin, Ireland2 Newcastle University, Newcastle upon Tyne, United Kingdom

Abstract

Traditionally, metabolomics in nutrition research is applied to fasting samples, and while such an approach has been successful, a number of studies are beginning to emerge where metabolomics has been applied to the time course of a dietary challenge study. Analysing such dynamic metabolomic data has been successful on two fronts: (1) identifying metabolic phenotypes in the predisease state and (2) identifying subtle metabolic changes following dietary interventions. This chapter gives an overview of the key studies to date with a focus on human ...

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