Bioconjugation Reactions in Living Cells
Development, Advances, and Applications of Glycan-Specific Technologies
Laura Alberch and Kevin J. Yarema, Department of Biomedical Engineering and the Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, USA
Bioorthogonal ligation reactions, in which synthetic organic chemistry can be accomplished in a physiological milieu including in living cells and animals, have flourished over the past two decades or so with the development of a profusion of coupling partners. This chapter gives an overview of bioorthogonal ligations including the best known example of this approach—the azide–alkyne “click” reaction—but also covers lesser known, more specialized, and ...
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