Micro-Drops and Digital Microfluidics

Book description

After spending over 12 years developing new microsystems for biotechnology û especially concerned with the microfluidic aspects of these devices û Jean Berthier is considered a leading authority in the field. Now, following the success of his book, Microfluidics for Biotechnology, Dr. Berthier returns to explain how new miniaturization techniques have dramatically expanded the area of microfluidic applications and microsystems into microdrops and digital microfluidics.

Table of contents

  1. Front Cover
  2. Microdrops and Digital Microfluidics
  3. Copyright Page
  4. Contents (1/2)
  5. Contents (2/2)
  6. Series Editor’s Preface
  7. Preface
  8. Acknowledgments
  9. Chapter 1. Digital Microfluidics in Today’s Microfluidics
    1. 1.1 The Development of Microfluidics
    2. 1.2 The Advantages of Digital and Droplet Micro.uidics Compared to Conventional Microflows
    3. 1.3 The Respective Place of Digital and Droplet Microfluidics in Today’s Microfluidics
    4. 1.4 Summary
    5. References
  10. Chapter 2. Theory of Wetting
    1. 2.1 Introduction
    2. 2.2 Interfaces and Surface Tension (1/2)
    3. 2.2 Interfaces and Surface Tension (2/2)
    4. 2.3 Laplace Law and Applications (1/4)
    5. 2.3 Laplace Law and Applications (2/4)
    6. 2.3 Laplace Law and Applications (3/4)
    7. 2.3 Laplace Law and Applications (4/4)
    8. 2.4 Wetting—Partial or Total Wetting
    9. 2.5 Contact Angle—Young’s Law
    10. 2.6 Work of Adhesion, Work of Cohesion, and the Young–Dupré Equation
    11. 2.7 Capillary Force, Force on a Triple Line (1/3)
    12. 2.7 Capillary Force, Force on a Triple Line (2/3)
    13. 2.7 Capillary Force, Force on a Triple Line (3/3)
    14. 2.8 Measuring Surface Tension of Liquids (1/2)
    15. 2.8 Measuring Surface Tension of Liquids (2/2)
    16. 2.9 Surface Tension of Solids (1/2)
    17. 2.9 Surface Tension of Solids (2/2)
    18. 2.10 Minimization of the Surface Energy and Minimal Energy Surfaces
    19. 2.11 Summary
    20. References
  11. Chapter 3. The Physics of Droplets
    1. 3.1 Introduction
    2. 3.2 The Shape of Micro-drops
    3. 3.3 Drops on Inhomogeneous Surfaces (1/4)
    4. 3.3 Drops on Inhomogeneous Surfaces (2/4)
    5. 3.3 Drops on Inhomogeneous Surfaces (3/4)
    6. 3.3 Drops on Inhomogeneous Surfaces (4/4)
    7. 3.4 Drops Moving by Capillarity (1/2)
    8. 3.4 Drops Moving by Capillarity (2/2)
    9. 3.5 Contact Angle Hysteresis
    10. 3.6 Droplet Pinning
    11. 3.7 The Effect of Surfactants
    12. 3.8 Marangoni Convection (1/2)
    13. 3.8 Marangoni Convection (2/2)
    14. 3.9 Evaporation (1/3)
    15. 3.9 Evaporation (2/3)
    16. 3.9 Evaporation (3/3)
    17. 3.10 Summary
    18. References
  12. Chapter 4. Electrowetting Theory
    1. 4.1 Introduction
    2. 4.2 Theoretical Background (1/3)
    3. 4.2 Theoretical Background (2/3)
    4. 4.2 Theoretical Background (3/3)
    5. 4.3 Lippmann–Young Law and the Electrocapillary Equivalence
    6. 4.4 Saturation (1/3)
    7. 4.4 Saturation (2/3)
    8. 4.4 Saturation (3/3)
    9. 4.5 Hysteresis (1/2)
    10. 4.5 Hysteresis (2/2)
    11. 4.6 Working Range of EWOD Devices
    12. 4.7 Materials and Substrates (1/2)
    13. 4.7 Materials and Substrates (2/2)
    14. 4.8 Discussion: Special Substrates and New Concepts (1/2)
    15. 4.8 Discussion: Special Substrates and New Concepts (2/2)
    16. 4.9 Summary
    17. References
  13. Chapter 5. EWOD Microsystems
    1. 5.1 Introduction
    2. 5.2 Open and Covered EWOD Microsystems
    3. 5.3 Droplet Motion (1/6)
    4. 5.3 Droplet Motion (2/6)
    5. 5.3 Droplet Motion (3/6)
    6. 5.3 Droplet Motion (4/6)
    7. 5.3 Droplet Motion (5/6)
    8. 5.3 Droplet Motion (6/6)
    9. 5.4 Division of Droplets (1/4)
    10. 5.4 Division of Droplets (2/4)
    11. 5.4 Division of Droplets (3/4)
    12. 5.4 Division of Droplets (4/4)
    13. 5.5 Droplet Merging and Mixing
    14. 5.6 Dilution
    15. 5.7 Magnetic Beads in EWOD Microsystems
    16. 5.8 Architecture of EWOD Microsystems
    17. 5.9 Other EWOD Microsystems
    18. 5.10 Summary
    19. References
  14. Chapter 6. Biological Applications of EWOD
    1. 6.1 Introduction
    2. 6.2 Biological Liquids and Physiological Samples Compatible with EWOD Devices
    3. 6.3 Sample Collection and Analysis on a Lab-on-a-chip Platform
    4. 6.4 Polymerase Chain Reaction (PCR) on Digital Microfluidics Systems (1/2)
    5. 6.4 Polymerase Chain Reaction (PCR) on Digital Microfluidics Systems (2/2)
    6. 6.5 DNA Repair Microprocessor
    7. 6.6 Protein Analysis Coupled with Mass Spectrometry
    8. 6.7 Cell-on-a-chip Microsystems: Example of a Cell Concentrator
    9. 6.8 Summary
    10. References
  15. Chapter 7. Chemical Applications
    1. 7.1 Introduction
    2. 7.2 Non Aqueous Solvents on EWOD Chips (1/3)
    3. 7.2 Non Aqueous Solvents on EWOD Chips (2/3)
    4. 7.2 Non Aqueous Solvents on EWOD Chips (3/3)
    5. 7.3 Chemical Synthesis in Droplets in EWOD-based Systems (1/2)
    6. 7.3 Chemical Synthesis in Droplets in EWOD-based Systems (2/2)
    7. 7.4 Conclusions and Perspectives
    8. References
  16. Chapter 8. Acoustic Methods for Manipulating Droplets
    1. 8.1 Introduction
    2. 8.2 Digital Microfluidics (1/3)
    3. 8.2 Digital Microfluidics (2/3)
    4. 8.2 Digital Microfluidics (3/3)
    5. 8.3 Example 1: Acoustic Mixing
    6. 8.4 Example 2: Acoustic Droplet Actuation
    7. 8.5 Applications (1/3)
    8. 8.5 Applications (2/3)
    9. 8.5 Applications (3/3)
    10. 8.6 Summary
    11. Acknowledgements
    12. References
  17. Chapter 9. Introduction to Droplet Microfluidics and Multiphase Microflows
    1. 9.1 Introduction
    2. 9.2 Two-phase Flows: Plugs in Microchannels (1/3)
    3. 9.2 Two-phase Flows: Plugs in Microchannels (2/3)
    4. 9.2 Two-phase Flows: Plugs in Microchannels (3/3)
    5. 9.3 Two-phase Flows: Flowing Fluids Separated by an Interface (1/2)
    6. 9.3 Two-phase Flows: Flowing Fluids Separated by an Interface (2/2)
    7. 9.4 Droplets in Two-phase Flows (1/3)
    8. 9.4 Droplets in Two-phase Flows (2/3)
    9. 9.4 Droplets in Two-phase Flows (3/3)
    10. 9.5 Summary
    11. References
  18. Chapter 10. Epilog
    1. 10.1 Increasing the Domain of EWOD Applicability
    2. 10.2 Interconnecting the Different Microfluidic Toolboxes
    3. 10.3 Miniaturization: Nano-EWOD
    4. 10.4 Other Applications Specific to Digital Microfluidics
    5. 10.5 Summary
    6. References
  19. Index (1/2)
  20. Index (2/2)

Product information

  • Title: Micro-Drops and Digital Microfluidics
  • Author(s): Jean Berthier
  • Release date: February 2008
  • Publisher(s): William Andrew
  • ISBN: 9780080947396