Micro-Drops and Digital Microfluidics

Micro-Drops and Digital Microfluidics

by Jean Berthier
Released February 2008
Publisher(s): William Andrew
ISBN: 9780080947396

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Book description

After spending over 12 years developing new microsystems for biotechnology û especially concerned with the microfluidic aspects of these devices û Jean Berthier is considered a leading authority in the field. Now, following the success of his book, Microfluidics for Biotechnology, Dr. Berthier returns to explain how new miniaturization techniques have dramatically expanded the area of microfluidic applications and microsystems into microdrops and digital microfluidics.

Engineers interested in designing more versatile microsystems and students who seek to learn the fundamentals of microfluidics will all appreciate the wide-range of information found within Microdrops and Digital Microfluidics. The most recent developments in digital microfluidics are described in clear detail, with a specific focus on the computational, theoretical and experimental study of microdrops.

• Over 500 equations and more than 400 illustrations.
• Authoritative reporting on the latest changes in microfluidic science, where microscopic liquid volumes are handled as ""microdrops"" and separately from ""nanodrops.""
• A methodical examination of how liquid microdrops behave in the complex geometries of modern miniaturized systems and interact with different morphological (micro-fabricated, textured) solid substrates.
• A thorough explanation of how capillary forces act on liquid interfaces in contact with micro-fabricated surfaces.
• Analysis of how droplets can be manipulated, handled, or transported using electric fields (electrowetting), acoustic actuation (surface acoustic waves), or by a carrier liquid (microflow).
• A fresh perspective on the future of microfluidics.

Table of contents

  1. Cover
  2. Title page
  3. Table of Contents
  4. MICRO & NANO TECHNOLOGIES
  5. Copyright
  6. Dedication
  7. Series Editor’s Preface
  8. Preface
  9. Acknowledgments
  10. Chapter 1: Digital Microfluidics in Today’s Microfluidics
    1. 1.1 The Development of Microfluidics
    2. 1.2 The Advantages of Digital and Droplet Microfluidics Compared to Conventional Microflows
    3. 1.3 The Respective Place of Digital and Droplet Microfluidics in Today’s Microfluidics
    4. 1.4 Summary
  11. Chapter 2: Theory of Wetting
    1. 2.1 Introduction
    2. 2.2 Interfaces and Surface Tension
    3. 2.3 Laplace Law and Applications
    4. 2.4 Wetting—Partial or Total Wetting
    5. 2.5 Contact Angle—Young’s Law
    6. 2.6 Work of Adhesion, Work of Cohesion, and the Young–Dupré Equation
    7. 2.7 Capillary Force, Force on a Triple Line
    8. 2.8 Measuring Surface Tension of Liquids
    9. 2.9 Surface Tension of Solids
    10. 2.10 Minimization of the Surface Energy and Minimal Energy Surfaces
    11. 2.11 Summary
  12. Chapter 3: The Physics of Droplets
    1. 3.1 Introduction
    2. 3.2 The Shape of Micro-drops
    3. 3.3 Drops on Inhomogeneous Surfaces
    4. 3.4 Drops Moving by Capillarity
    5. 3.5 Contact Angle Hysteresis
    6. 3.6 Droplet Pinning
    7. 3.7 The Effect of Surfactants
    8. 3.8 Marangoni Convection
    9. 3.9 Evaporation
    10. 3.10 Summary
  13. Chapter 4: Electrowetting Theory
    1. 4.1 Introduction
    2. 4.2 Theoretical Background
    3. 4.3 Lippmann–Young Law and the Electrocapillary Equivalence
    4. 4.4 Saturation
    5. 4.5 Hysteresis
    6. 4.6 Working Range of EWOD Devices
    7. 4.7 Materials and Substrates
    8. 4.8 Discussion: Special Substrates and New Concepts
    9. 4.9 Summary
  14. Chapter 5: EWOD Microsystems
    1. 5.1 Introduction
    2. 5.2 Open and Covered EWOD Microsystems
    3. 5.3 Droplet Motion
    4. 5.4 Division of Droplets
    5. 5.5 Droplet Merging and Mixing
    6. 5.6 Dilution
    7. 5.7 Magnetic Beads in EWOD Microsystems
    8. 5.8 Architecture of EWOD Microsystems
    9. 5.9 Other EWOD Microsystems
    10. 5.10 Summary
  15. Chapter 6: Biological Applications of EWOD
    1. 6.1 Introduction
    2. 6.2 Biological Liquids and Physiological Samples Compatible with EWOD Devices
    3. 6.3 Sample Collection and Analysis on a Lab-on-a-chip Platform
    4. 6.4 Polymerase Chain Reaction (PCR) on Digital Microfluidics Systems
    5. 6.5 DNA Repair Microprocessor
    6. 6.6 Protein Analysis Coupled with Mass Spectrometry
    7. 6.7 Cell-on-a-chip Microsystems: Example of a Cell Concentrator
    8. 6.8 Summary
  16. Chapter 7: Chemical Applications
    1. 7.1 Introduction
    2. 7.2 Non Aqueous Solvents on EWOD Chips
    3. 7.3 Chemical Synthesis in Droplets in EWOD-based Systems
    4. 7.4 Conclusions and Perspectives
  17. Chapter 8: Acoustic Methods for Manipulating Droplets
    1. 8.1 Introduction
    2. 8.2 Digital Microfluidics
    3. 8.3 Example 1: Acoustic Mixing
    4. 8.4 Example 2: Acoustic Droplet Actuation
    5. 8.5 Applications
    6. 8.6 Summary
    7. Acknowledgements
  18. Chapter 9: Introduction to Droplet Microfluidics and Multiphase Microflows
    1. 9.1 Introduction
    2. 9.2 Two-phase Flows: Plugs in Microchannels
    3. 9.3 Two-phase Flows: Flowing Fluids Separated by an Interface
    4. 9.4 Droplets in Two-phase Flows
    5. 9.5 Summary
  19. Chapter 10: Epilog
    1. 10.1 Increasing the Domain of EWOD Applicability
    2. 10.2 Interconnecting the Different Microfluidic Toolboxes
    3. 10.3 Miniaturization: Nano-EWOD
    4. 10.4 Other Applications Specific to Digital Microfluidics
    5. 10.5 Summary
  20. Index
  21. MICRO & NANO TECHNOLOGIES

Product information

  • Title: Micro-Drops and Digital Microfluidics
  • Author(s): Jean Berthier
  • Release date: February 2008
  • Publisher(s): William Andrew
  • ISBN: 9780080947396