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Microarray Analysis by Kal Sharma

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CHAPTER 2

Microarray Analysis

Chapter Objectives

        •   Phosphoramidite Synthesis

        •   First- and Second-Generation Confocal Scanning Microscopes

        •   Five Steps and Ten Tips

        •   Microarray Surface

        •   Glass Substrate

        •   NanoPrint Microarrayer

        •   Synthetic Oligonucleotide from Six Bases (A, C, G, T, X, and Y)

        •   Target–Probe Hybridization

2.1 Molecular Basis for Disease

Pauling came up with the molecular basis for disease, the connection/correlation between altered proteins, disease, and gene mutations. In 1949, he showed that hemoglobin in patients with sickle-cell anemia migrated discordantly in gel electrophoretic assays compared with hemoglobin in normal patients. The aberration ...

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