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Microarray Analysis by Kal Sharma

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CHAPTER 7

Statistical Characterization and Normalization

Chapter Objectives

        •   Normalization

        •   Systematic Variation, Dye Bias

        •   Housekeeping Genes

        •   Spiked Controls

        •   All Genes in Array

        •   Global Normalization

        •   Within-Slide, Paired-Slide, Multiple-Slide Normalizations

        •   k-Means Clustering

        •   Self-Organizing Maps

        •   Relevance Networks

        •   Bayesian Clustering

7.1 Housekeeping Genes and Normalization

There are many sources of systematic variation in microarray experiments that affect the measured gene-expression levels. Normalization is the term used to describe the process of removing such variation, for example, for differences in labeling ...

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