People read online material differently than they do printed material, so be sure to keep online readers in mind when designing your site.
SharePoint Designer can help you check your site against accessibility guidelines and compatibility standards when you choose a color scheme.
Take a practical approach to customizing your site. Concentrate on keeping your site up to date with information that people will use, and organized in a way that they can find it.
Define policies and tell other content authors of your site what they must do to keep the site legal and accessible.
Use page layouts and master pages to minimize the amount of maintenance and customizations you need to complete on pages to keep your site legal.