Keeping third-party applications up-to-date is a very important step to patch security vulnerabilities in your applications. Microsoft applications are updated through WSUS or Software Update. Next, you have the most commonly hit applications like Adobe and Java, simply because these applications have integrations to Internet Browsers.
The safest browser right now is Microsoft Edge.
Why you may ask? Because Google Chrome, Internet Explorer and Firefox have been on the market much longer and have far more users. Attackers simply attack were they have the largest possible impact.
Internet Explorer that comes with Windows 10 has its own Flash, and is now updated though Microsoft Updates channel. This means ...