
142 Modeling and Inverse Problems in the Presence of Uncertainty
4.4 Example: CFSE Label Decay
We return to the CFSE cell proliferation ex ample of Section 3.5.3 a nd in
particular Equation (3.73) characterizing CFSE label decay as part of the
cell proliferation system (3.75). Current mathematical models, such as those
described in Section 3.5.3, allow one to estimate proliferation and death rates
in terms of a CFSE florescence intensity (FI) structure variable as a surrogate
for division number, so the manner in which CFSE naturally decays directly
affects the cell turnover parameter estimates. Thus, the loss rate function,
˙x = v(t, x), is of vital