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Modeling of Microscale Transport in Biological Processes

Book Description

Modeling of Microscale Transport in Biological Processes provides a compendium of recent advances in theoretical and computational modeling of biotransport phenomena at the microscale. The simulation strategies presented range from molecular to continuum models and consider both numerical and exact solution method approaches to coupled systems of equations.

The biological processes covered in this book include digestion, molecular transport, microbial swimming, cilia mediated flow, microscale heat transfer, micro-vascular flow, vesicle dynamics, transport through bio-films and bio-membranes, and microscale growth dynamics.

The book is written for an advanced academic research audience in the fields of engineering (encompassing biomedical, chemical, biological, mechanical, and electrical), biology and mathematics. Although written for, and by, expert researchers, each chapter provides a strong introductory section to ensure accessibility to readers at all levels.

  • Features recent developments in theoretical and computational modeling for clinical researchers and engineers
  • Furthers researcher understanding of fluid flow in biological media and focuses on biofluidics at the microscale
  • Includes chapters expertly authored by internationally recognized authorities in the fundamental and applied fields that are associated with microscale transport in living media

Table of Contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Contributors
  6. Preface
  7. Chapter 1: Molecular Simulations of Complex Membrane Models
    1. Abstract
    2. 1.1. Introduction
    3. 1.2. Unsaturated Carbon Chains
    4. 1.3. Membrane Proteins
    5. 1.4. Sterols
    6. 1.5. Eukaryotic Membranes
    7. 1.6. Prokaryotic Membranes
    8. 1.7. Viral Membranes
    9. 1.8. Membrane Fusion
    10. 1.9. Graphitic Nanomaterials
    11. 1.10. Nanoparticles
    12. 1.11. On-Going Work
    13. 1.12. Outlook and Conclusion
    14. References
  8. Chapter 2: Microbial Strategies for Oil Biodegradation
    1. Abstract
    2. Acknowledgements
    3. 2.1. Introduction
    4. 2.2. Overview of the Biodegradation Process
    5. 2.3. Microbial Growth Modes on Oily Substrates
    6. 2.4. Microscale Modeling Considerations
    7. 2.5. Summary and Outlook
    8. References
  9. Chapter 3: Modeling and Measurement of Biomolecular Transport and Sensing in Microfluidic Cell Culture and Analysis Systems
    1. Abstract
    2. 3.1. Introduction
    3. 3.2. Basic Principles of Microscale Cell Culture
    4. 3.3. Theory and Equations: Fluid Flow, Mass Transport, and Biochemical Reactions
    5. 3.4. Review of Microfluidic Transport Models
    6. 3.5. Review of Theoretical Model Experimental Validation and Microfluidic On-Chip Analysis Highlights
    7. 3.6. Summary and Conclusions
    8. References
  10. Chapter 4: Coupling Microscale Transport and Tissue Mechanics: Modeling Strategies for Arterial Multiphysics
    1. Abstract
    2. Acknowledgements
    3. 4.1. Introduction
    4. 4.2. Brief on Arterial Tissues
    5. 4.3. Arterial Multiphysics Modeling
    6. 4.4. An Axisymmetric Case Study
    7. 4.5. Conclusions
    8. Appendix A. Along-the-Chord Collagen Fiber Tangent Modulus
    9. Appendix B. Microstructure of Aortic Media Layer
    10. References
  11. Chapter 5: Modeling Cystic Fibrosis and Mucociliary Clearance
    1. Abstract
    2. Acknowledgements
    3. 5.1. Mucociliary Clearance and Cystic Fibrosis
    4. 5.2. Newtonian Models
    5. 5.3. Rheology of Mucus and Non-Newtonian Models
    6. 5.4. Concluding Remarks
    7. References
  12. Chapter 6: Intracellular Microfluid Transportation in Fast Growing Pollen Tubes
    1. Abstract
    2. 6.1. Introduction
    3. 6.2. Modeling Fluid Flow of Fountain Streaming in Pollen Tubes
    4. 6.3. Modeling Intracellular Microfluid Transportation in Pollen Tubes
    5. 6.4. Results and Discussion
    6. 6.5. Conclusions
    7. References
  13. Chapter 7: Microorganisms and Their Response to Stimuli
    1. Abstract
    2. 7.1. Introduction
    3. 7.2. Swimming Dynamics
    4. 7.3. Response to Stimuli
    5. 7.4. Non-Flowing Suspensions
    6. 7.5. Flowing Suspensions
    7. 7.6. Conclusions
    8. References
  14. Chapter 8: Nano-Swimmers in Lipid-Bilayer Membranes
    1. Abstract
    2. 8.1. Introduction
    3. 8.2. Methods
    4. 8.3. Results
    5. 8.4. Conclusions
    6. References
  15. Chapter 9: Phase Field Modeling of Inhomogeneous Biomembranes in Flow
    1. Abstract
    2. 9.1. Motivation
    3. 9.2. Energy of the System
    4. 9.3. Hydrodynamic Models
    5. 9.4. Inhomogeneous Membranes
    6. 9.5. Numerical Methods
    7. 9.6. The Phase Field Method
    8. 9.7. Phase Field Models for Inhomogeneous Membranes
    9. References
  16. Chapter 10: Modeling and Experimental Analysis of Thermal Therapy during Short Pulse Laser Irradiation
    1. Abstract
    2. 10.1. Introduction
    3. 10.2. Methods
    4. 10.3. Results and Discussion
    5. 10.4. Conclusions
    6. References
  17. Chapter 11: Micro-Scale Bio-Heat Diffusion Using Green's Functions
    1. Abstract
    2. 11.1. Introduction
    3. 11.2. Balance Equations
    4. 11.3. Dual-Phase Lag Bio-Heat Diffusion Equation
    5. 11.4. Boundary and Initial Conditions
    6. 11.5. Temperature Solution in Finite Regular Tissues with Homogeneous Boundary Conditions
    7. 11.6. Temperature Solution in Finite Regular Tissues with Non-Homogeneous Boundary Conditions
    8. 11.7. Green's Functions for Finite Regular Tissues
    9. 11.8. Temperature Distribution in a Laser-Irradiated Biological Tissue
    10. 11.9. Conclusions
    11. Appendix A.
    12. Appendix B.
    13. References
  18. Chapter 12: Microstructural Influences on Growth and Transport in Biological Tissue—A Multiscale Description
    1. Abstract
    2. Acknowledgements
    3. 12.1. Introduction
    4. 12.2. Formulation: Nutrient-Limited Microscale Growth of a Porous Medium
    5. 12.3. Multiple Scales Analysis
    6. 12.4. Results
    7. 12.5. Discussion
    8. References
  19. Chapter 13: How Dense Core Vesicles Are Delivered to Axon Terminals – A Review of Modeling Approaches
    1. Abstract
    2. Acknowledgement
    3. 13.1. Introduction
    4. 13.2. Review of Relevant Literature
    5. 13.3. Mathematical Models of DCV Transport and Accumulation in Axon Terminals
    6. 13.4. Results and Discussion
    7. 13.5. Future Work
    8. 13.6. Conclusions
    9. References
  20. Chapter 14: Modeling of Food Digestion
    1. Abstract
    2. 14.1. Introduction
    3. 14.2. The Complexity of Food Digestion and Absorption
    4. 14.3. Development of Digestion and Absorption Modeling
    5. 14.4. Microscale Modeling of Food Digestion and Absorption
    6. 14.5. Conclusion
    7. References
  21. Index