In this section we will
illustrate the application of MCP-Mod with two examples and show how
to implement it using SAS. The first example illustrates the original
MCP-Mod procedure for normally distributed data, as described in 7.2.1 Original MCP-Mod Approach
, using a model selection approach. In this situation
can be used for the
MCP step, because it allows for the calculation of the required multiplicity
can be used for fitting the associated nonlinear regression models and estimating target doses. The second example illustrates a more complex application of MCP-Mod in the context of a linear mixed-effect model. In this situation the generalized, ...