7.5 Analysis Examples Using SAS

7.5.1 The optcont Macro

In this section we will illustrate the application of MCP-Mod with two examples and show how to implement it using SAS. The first example illustrates the original MCP-Mod procedure for normally distributed data, as described in 7.2.1 Original MCP-Mod Approach, using a model selection approach. In this situation proc glimmix can be used for the MCP step, because it allows for the calculation of the required multiplicity adjusted p-values. Proc nlmixed can be used for fitting the associated nonlinear regression models and estimating target doses. The second example illustrates a more complex application of MCP-Mod in the context of a linear mixed-effect model. In this situation the generalized, ...

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