9

CHAPTER

Genes, Behavior, and Symptoms

There are some natures that have a predisposition to grief, as others have to disease. … The causes that have made me wretched would probably not have discomposed, or at least, more than discomposed, another. We are all differently organized: and that I feel acutely is no more my fault (although it is my misfortune) than that another feels not, is his. We did not make ourselves, and if the elements of unhappiness abound more in the nature of one man than another, he is but the more entitled to our pity and our forbearance.

—Lord Byron, quoted in Jamison (1994)

The first part of this book showed that childhood adversity, by itself, does not necessarily cause symptoms in adults. Instead, adverse events ...

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