Nanocapsule formation by nanocrystals

Gregori B. Romero*
Wolfgang Brysch**
Cornelia M. Keck
Rainer H. Müller**    Free University of Berlin, Berlin, Germany**    Athenion GmbH, Berlin, Germany    PharmaSol GmbH, Berlin, Germany


A sufficient bioavailability of active ingredients is the prerequisite for high quality nutraceuticals, functional beverages, well-being or energy drinks, and functional foods, in general for all products supporting health and well-being. However, poorly soluble bioactives often have a low bioavailability, which may limit their effectiveness considering the low doses used in these products. The BioSmart technology, based on nanocrystals, is presented for increasing the oral bioavailability. BioSmarts are particles ...

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