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Nanomaterials in Glucose Sensing by Ning Wang, Krishna Burugapalli

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3. Signal generation and detection of glucose

Electrochemical and optical methods are commonly utilized to generate and detect measurable signals that are glucose concentration-dependent. Oliver et al. and Pickup et al. describe the principles, advantages and disadvantages of the different optical methods [4, 10], while that of electrochemical methods are reviewed in detail by Heller and Feldman [1].

3.1 Electrochemical methods

Figure 3-1 depicts the major electrochemical methods used to convert the free energy of glucose into an electrical signal. Broadly they can be classified as either non-enzymatic or enzymatic methods. The former are usually non-specific and suffer from signal inaccuracies due to interferents and electrode poisoning, ...

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