
466 Nanosensors: Physical, Chemical, and Biological
formula C
10
H
16
N
2
O
3
S. The gold electrode was now prepared for hybridization
with DNA analytes. The gold NP hybridization indicator was bound to the
hybridized target by the interaction between the biotin group of the target
and the SA group of the gold NP. Subsequent silver deposition on the gold
NP resulted in discernible signal amplication. With the low background
signal achieved by electrode-surface modication and selection, sensitive
(high signal-to-noise ratio) electrochemical detection of the hybridization
event using the silver-enhanced gold NP approach was demonstrated ...