Chapter 4

Nanostructured nanoparticles for improved drug delivery

Jean M. Rabanel
Pierre L. Latreille
Augustine Lalloz
Patrice Hildgen
Xavier Banquy    University of Montreal, Montreal, QC, Canada

Abstract

Solid drug nanocarriers such as polymer aggregates, solid lipid nanoparticles, silica nanoparticles, organic–inorganic hybrid particles nanoparticles, nanocapsules, and vesicles are nanoscaled objects that are not homogeneous in their structural organization. Such structural heterogeneity can be the result of a rationale design in an objective to control release kinetics and carrier interactions with biological media and tissues. Control of these parameters could potentially lead to improved drug bioavailability, organ targeting, drug stability, ...

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