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Nanostructures for Drug Delivery by Alexandru Mihai Grumezescu, Ecaterina Andronescu

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Chapter 6

Niosomes: a novel approach in modern drug delivery systems

Sepideh Khoee*
Morteza Yaghoobian***    University of Tehran, Tehran, Iran**    Shahid Beheshti Medical University, Tehran, Iran

Abstract

Niosomes as a novel drug delivery system is a nonionic surfactant-based vesicle.The twofold structure of surfactant molecules encourages them to orient in bilayer architecture. In this two-layered structure, hydrophilic and hydrophobic ends of surfactant tend to arrange into external and internal sites, respectively. This lamellar morphology allows us to entrap two kinds of drugs in a unique carrier simultaneously. Several factors affect the structure of niosomes, such as: the nature and type of surfactants, amount of cholesterol, the critical ...

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