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Nanostructures for Drug Delivery by Alexandru Mihai Grumezescu, Ecaterina Andronescu

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Chapter 14

Polymer-based nanocarriers for therapeutic nucleic acids delivery

Weien Yuan
Hui Li    Shanghai Jiao Tong University, Shanghai, China

Abstract

In the last several decades, therapeutic nucleic acids including siRNAs, miRNAs, anti-miRNAs, antisense oligonucleotides, and plasmids have received remarkable attention in the drug discovery and development community due to their great potential for directly modulating previously undruggable therapeutic targets with high specificity and low toxicity. However, many nucleic-acid-based drugs also suffer from poor bioavailability and pharmacokinetic profile due to their poor stability in the biological environment and inability to efficiently cross the cell membrane. Thus, various formulation approaches ...

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