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Nanostructures for Drug Delivery by Alexandru Mihai Grumezescu, Ecaterina Andronescu

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Chapter 16

Lipid-based nanocarriers for ocular drug delivery

Ragwa M. Farid*
Noha S. El-Salamouni*
Amal H. El-Kamel**
Safaa S. El-Gamal***    Pharos University in Alexandria, Alexandria, Egypt**    Alexandria University, Alexandria, Egypt

Abstract

Ocular drug delivery remains challenging because of the complex nature and structure of the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas systemic administration requires high doses resulting in significant toxicity. There is a need to develop novel drug delivery carriers capable of increasing ocular bioavailability and decreasing both local and systemic cytotoxicity. Recently, the emergence of lipid-based nanocarriers has provided a viable means of enhancing the ...

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