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Nanostructures for Drug Delivery by Alexandru Mihai Grumezescu, Ecaterina Andronescu

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Chapter 18

Pathogen-specific nucleic acid aptamers as targeting components of antibiotic and gene delivery systems

Canan Ozyurt
Burhan Bora
Ozge Ugurlu
Serap Evran    Ege University, Bornova-Izmir, Turkey

Abstract

Inefficient delivery of antibiotics to the infection microenvironment, side effects of high-dose antibiotic use, as well as antimicrobial drug resistance are major global issues that remain to be solved. Efficient drug delivery systems and novel antimicrobial treatment strategies are urgently needed. Cell-specific aptamers are excellent molecules for specific targeting of microbial cells. Aptamers are single-stranded DNA or RNA molecules, which are able to selectively bind to their targets with high affinity. In this chapter, we first ...

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