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Nanostructures for Drug Delivery by Alexandru Mihai Grumezescu, Ecaterina Andronescu

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Chapter 22

Advancement in pulmonary drug delivery systems for treatment of tuberculosis

Amit K. Goyal
Tarun Garg
Sourav Bhandari
Goutam Rath    ISF Educational Society, Moga, India

Abstract

Tuberculosis (TB) is the second most deadly infectious disease around the world. Chemotherapy of TB is complicated by the need of multidrug regimens that need to be administered over long periods. Most oral antitubercular drugs (ATDs) presently in use fail to achieve high drug concentration in the lung. For administration of ATDs, lungs are an attractive and versatile route used since ancient times for treatment of pulmonary and airway diseases. But there are numerous barriers in the respiratory tract that restrict the pulmonary delivery of drugs to the target ...

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