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Nanostructures for Drug Delivery by Alexandru Mihai Grumezescu, Ecaterina Andronescu

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Chapter 23

Nanosized devices as antibiotics and antifungals delivery: past, news, and outlook

Pio Maria Furneri*
Giulio P. Petronio**
Virginia Fuochi*
Sarha Cupri*
Rosario Pignatello**    University of Catania, Catania, Italy**    IRCCS San Raffaele Pisana, BioBIM—Multidisciplinary Interinstitutional BioBank, Rome, Italy

Abstract

Clinical treatment of bacterial and fungal infections often meets many drawbacks associated with the low bioavailability of active agents, adverse side effects, difficulty in penetrating and concentrating inside the target cells, intrinsic or acquired resistance of microorganisms.

In recent years, nanotechnology has driven efforts toward this therapeutic area, proposing efficient colloidal (nanosized) delivery systems ...

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