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Nanostructures for Drug Delivery by Alexandru Mihai Grumezescu, Ecaterina Andronescu

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Chapter 26

Targeted drug delivery via chitosan-coated magnetic nanoparticles

Gozde Unsoy
Ufuk Gunduz    Middle East Technical University, Ankara, Turkey

Abstract

The devastating effects of chemotherapeutic agents have been observed on healthy cells as well as tumor cells because they are nonspecifically distributed all over the body. This treatment results in hazardous side effects and excessive toxicity. Targeted drug delivery has emerged to overcome the lack of specificity of conventional chemotherapy. Nanoparticles used for drug targeting are promising to circumvent these challenges, by enabling the localization of high drug amounts at the site of disease. When drugs are conjugated on nanoparticles, it is possible to increase their half-life ...

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