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Nanostructures for Novel Therapy by Alexandru Mihai Grumezescu, Denisa Ficai

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Chapter 21

The effect of nanostructured surfaces on stem cell fate

Dorothee Schipper
Patrick Babczyk
Fatma Elsayed
Stephanie E. Klein
Margit Schulze
Edda Tobiasch    Bonn-Rhine-Sieg University of Applied Sciences, Rheinbach, Germany

Abstract

The ability of stem cells to self-renew and differentiate into multiple lineages has made them attractive candidates for therapeutic interventions. Adult stem cells are a promising source for regenerative medicine approaches since they are easy to obtain, and bear a lower risk of immune rejection and tumor formation, compared to embryonic stem cells or iPS cells. Controlling their fate tightly is still the key challenge on their way from bench to bedside use. While conventional methods are based mainly on chemical ...

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