What’s Wrong with Their Mice?
What a pitiful, what a sorry thing to have said that animals are machines bereft of understanding and feeling, which perform their operations always in the same way, which learn nothing, perfect nothing, etc.!
—Voltaire, Dictionnaire philosophique portatif, 17641
Tread softly when approaching a mouse model of a human psychiatric disease.
—Jacqueline Crawley, What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, 2007
We take the title of this chapter from Jacqueline Crawley’s What’s Wrong with My Mouse? from which we have learned a great deal about the world of animal modeling of behavioral disorders (Crawley 2007).2 Given the limitations that have long surrounded experimental ...