Metallic biomaterials have found a plethora of applications as medical devices. However, the long-term performance of these materials is highly dependent on their ability to withstand synergistic effects of corrosion and wear. Loss of surface integrity and subsequent leaching of metal ions and particles into the peri-implant environment may undermine biocompatibility of metallic implants, also potentially causing untimely loss of mechanical function and device failure. This chapter reviews key issues relating to cytotoxicity and biocompatibility.
Metallic biomaterials are employed in various ...