Because there are so many ways to use Nuendo, first ask yourself how you anticipate using Nuendo every day. This will influence how you choose a computer, audio interface, and other hardware that will make up your system. This also influences how you install and configure Nuendo.
Ask yourself a few questions about what type of audio production you intend to do. Of course, Nuendo can be reconfigured later if your needs change, but it helps to outline your intended uses before moving ahead with installation and configuration.
Answer these questions:
Are you producing music or mostly sound design? Nuendo ...