Chapter 4

Sugars, Glucocorticoids, and the Hypothalamic Controls of Appetite

Thomas W. Castonguay and Samantha Hudgins,    University of Maryland, College Park, MD, United States


In this chapter we will review the data from inquiries into each of three sets of experiments from our laboratory that link the intake of fructose to physiological conditions that favor the development of excess body fat. First, over the past 10 years we have examined how fructose consumption bypasses glucose regulatory mechanisms that result in hypertriglyceridemia with as little as overnight access. Second, we have also demonstrated that fructose can cause an increase in 11β-hydroxysteroid dehydrogenase in liver, adipose tissue, and the brain—again leading ...

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