Chapter 17

Vitamin E Isoform-Specific Functions in Allergic Inflammation and Asthma

Joan M. Cook-Mills,    Northwestern University, Chicago, IL, United States

Abstract

Asthma and allergic lung disease occur as complex environmental and genetic interactions. Epidemiological studies and randomized prevention trials have demonstrated the potential of a number of protective dietary factors for asthma, including the vitamin E isoform α-tocopherol. However, reports for vitamin E have seemingly varied outcomes regarding benefits. These seemingly varied outcomes are consistent with mechanistic studies of opposing functions of the vitamin E isoforms α-tocopherol and γ-tocopherol. Moreover, the variation in global prevalence of asthma may be explained, ...

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