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Nutrition and Functional Foods for Healthy Aging by Ronald Ross Watson

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Chapter 28

Late-Onset Caloric Restriction Alters Skeletal Muscle Metabolism

Mechanisms from Animal and Human Studies

Chiao-nan Chen,    Chang Gung University, Taoyuan, Taiwan

Abstract

Skeletal muscle is an organ critical for generating movement and fueling metabolism. Age-related muscle dysfunction, including loss of muscle mass and strength, not only impairs elder persons’ physical function but also decreases their peripheral insulin sensitivity. The key contributor to the age-related muscle dysfunction is impaired mitochondrial function. Mitochondrial dysfunction results in the alteration of cellular metabolic patterns away from mitochondrial respiration and toward glycolysis, which decreases cells’ energy-generation capacity. In addition, ...

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