A. SCIENTIFIC BASIS

Carcinogenesis

1. The answer is a.

The two most commonly recognized models of cancer development; clonal evolution and development of the cancer stem cell suggest a path to metastatic disease. The plasticity model proposed that plasticity exists between the non-cancer stem cell and cancer stem cell compartments such that there is bidirectional conversion to malignancy. The inflammation theory proposes that inflammation is associated with the development of cancer. CNPP, Page 4.

2. The answer is c.

Disease-causing mutations can occur in the germline, inherited DNA originally from the egg and sperm, or in the somatic cells. DNA is found in every cell in the body except the sperm and the egg. CNPP, Page 6.

3. The answer is c. ...

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