G. TARGETED THERAPY

188. Proteins found or expressed on the cell membrane that serve as a bridge between an extracellular and intracellular environment are called:

  1. Growth factor receptors
  2. Growth factor ligands
  3. Oncoprotein
  4. Oncogenes

189. Allen has non-small cell lung cancer and has begun treatment with gefitinib (Iressa), an epidermal growth factor receptor–tyrosine kinase inhibitor. Which of the following is considered to be a common side effect of this treatment?

  1. Anaphylaxis
  2. Hypotension
  3. Skin rash
  4. Pancytopenia

190. Monoclonal antibodies interfere with cell membrane-bound targets by which of the following mechanisms?

  1. Activating ligand receptor and antibody-dependent cellular cytotoxicity
  2. Blocking complement-mediated cytotoxicity activation ...

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