G. TARGETED THERAPY

188. The answer is a.

Growth factor receptors are proteins found or expressed on the cell membrane that serve as a bridge between extracellular and intracellular environments. CNPP, Page 654.

189. The answer is c.

The major side effects of gefitinib (Iressa) are skin rash and diarrhea. It rarely causes any allergic-type reaction, hypotension, or effect on the bone marrow. CNPP, Pages 667–669.

190. The answer is b.

Monoclonal antibodies interfere with cell membrane-bound targets by blocking ligand receptor activation, antibody-dependent cellular cytotoxicity, complement-mediated cytotoxicity, and immune modulation. CNPP, Page 654.

191. The answer is c.

The most common side effects reported by 774 patients are asthenia/malaise, ...

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