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Functionalized microstructured optical fibers for specific nucleic acid detection

A. Candiani,  and A. Cucinotta     University of Parma, Parma, Italy

Abstract

A new sensing platform for specific DNA strand detection based on microstructured optical fiber Bragg gratings and peptide nucleic acid probes is presented. To achieve optical signal amplification, DNA-functionalized gold nanoparticles are used in a sandwich-like system assay, showing high sensitivity and repeatability of the results. Besides the particular technological approach, we report some practical applications implemented in the medical field and in the food industry.

Keywords

Biosensing; Bragg gratings; DNA detection; Functionalized nanoparticles; Microstructured optical fibers (MOFs) ...

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