Anything that is surprising can have a powerful effect on an audience; for example, if you make people laugh in a serious PowToon, they often remember the point you were making when you made them laugh.
It is possible to create a wonderful presentation in MS PowerPoint. That's a fact.
For a masterclass in design and how to use presentation software and presentation techniques, I would recommend slide:ology – The Art and Science of Creating Great Presentations, Nancy Duarte, O'Reilly Media Inc. 2008.
Unfortunately, most of the time, MS PowerPoint has been used in a very dull and lackluster way by people who are not prepared to learn how to use it well, and who are unprepared to incorporate some ...