Book description
Progenitor and stem cells have the ability to renew themselves and change into a variety of specialised types, making them ideal materials for therapy and regenerative medicine. Progenitor and stem cell technologies and therapies reviews the range of progenitor and stem cells available and their therapeutic application.Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair.
With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology.
- Reviews the range of progenitor and stem cells available and outlines their therapeutic application
- Examines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells
- Includes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies
Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributor contact details
- Introduction
-
Part I: Basic principles of stem cells
- Chapter 1: Basic principles for stem cell culture
-
Chapter 2: Basic principles of human embryonic stem cells
- Abstract:
- 2.1 Introduction: biological properties of human embryonic stem cells (hESC)
- 2.2 Historical overview
- 2.3 Human embryonic stem cells (hESC) in therapy – current status and strategies for the future
- 2.4 Human embryonic stem cells (hESC) in drug discovery – current status and strategies for the future
- 2.5 Specific mutation-carrying (SMC) human embryonic stem cells (hESC)
- 2.6 Human embryonic stem cells (hESC) utilization, the next step
- 2.7 Conclusion
- Chapter 3: Basic principles in generating induced pluripotent stem cells
-
Chapter 4: Basic principles of amniotic fluid and placenta stem cells
- Abstract:
- 4.1 Introduction
- 4.2 Amniotic fluid and placenta in developmental biology
- 4.3 Isolation and characterization of progenitor cells
- 4.4 Differentiation of amniotic fluid- and placenta-derived progenitor cells
- 4.5 In vivo behavior of amniotic fluid stem cells
- 4.6 Amniotic fluid and placenta for cell therapy
- 4.7 Conclusion
- 4.8 Acknowledgment
-
Chapter 5: Basic principles of cord blood stem cells
- Abstract:
- 5.1 Introduction: history of cord blood stem cell technology
- 5.2 Cord blood collection, processing and storage
- 5.3 Public and private cord blood banking
- 5.4 Cord blood haemopoietic stem cell transplantation
- 5.5 Cord blood mesenchymal stem cells
- 5.6 Current research and future developments
- 5.7 Cord blood transfusion
- 5.8 Conclusion
-
Chapter 6: Basic principles of multipotent stem cells
- Abstract:
- 6.1 Introduction
- 6.2 Hematopoietic stem cells (HSC)
- 6.3 Mesenchymal stem cells (MSC)
- 6.4 Adult stem cells with broader potential
- 6.5 In vitro and in vivo differentiation potential of multipotent adult progenitor cells (MAPC)
- 6.6 Immunomodulatory properties of multipotent adult progenitor cells (MAPC)
- 6.7 Conclusion
-
Part II: Enabling cell therapy
-
Chapter 7: Intellectual property claims to stem cell technologies: research, clinical testing and product sales
- Abstract:
- 7.1 Introduction
- 7.2 International overview of patent laws and stem cell policies
- 7.3 Introduction to the international stem cell patent landscape
- 7.4 Human embryonic stem cell patents
- 7.5 Advances in induced pluripotent stem cell patents (iPS cells)
- 7.6 Models for access to, and management of, stem cell patents
- 7.7 Conclusion
- 7.8 Acknowledgments
-
Chapter 8: Regulatory considerations of stem and progenitor cell-based products: US Food and Drug Administration
- Abstract:
- 8.1 Introduction
- 8.2 Preparing the cellular component: chemistry, manufacturing and control considerations
- 8.3 Preclinical testing: pharmacology/toxicology considerations
- 8.4 Clinical trial considerations
- 8.5 Combination products: considerations when combining stem/progenitor cells with other components
- 8.6 Conclusion and future regulatory tools development
- 8.7 Acknowledgments
- Chapter 9: Cell therapy commercialisation
- Chapter 10: Stem cell tourism
-
Chapter 7: Intellectual property claims to stem cell technologies: research, clinical testing and product sales
-
Part III: Tissue-specific progenitor cells
-
Chapter 11: Adipose tissue-derived stem cell biology and therapy
- Abstract:
- 11.1 Introduction
- 11.2 Characterization of adipose tissue-derived stromal cells
- 11.3 Advantages of adipose tissue-derived stem cells over other cell sources
- 11.4 Adipose tissue-derived stromal cells for cardiovascular repair: a joint clinical and experimental approach
- 11.5 Conclusion: perspectives and open questions
- 11.6 Acknowledgements
- Chapter 12: Umbilical cord blood (UCB) progenitor and stem cell biology and therapy
- Chapter 13: Auditory progenitor stem cell biology and therapy
- Chapter 14: Olfactory mucosa: neural stem and progenitor cells for nervous system repair and cell models of brain disease
- Chapter 15: Oral cavity progenitor and stem cell biology and therapy
- Chapter 16: Bone marrow mesenchymal progenitor and stem cell biology and therapy
- Chapter 17: Progenitor and stem cell therapies for cartilage repair
- Chapter 18: Cardiac stem and progenitor cell biology and therapy
- Chapter 19: Renal progenitor and stem cell biology and therapy
-
Chapter 20: Lung progenitor and stem cell biology and therapy
- Abstract:
- 20.1 Introduction: definitions of a diverse population
- 20.2 Lung development and stem cell zones
- 20.3 Resident lung stem cells and their niches
- 20.4 Circulating bone marrow-derived stem cells which home to the lung
- 20.5 Techniques for identification of lung stem cells
- 20.6 Disorders of lung stem cells and clinical applications in lung diseases
- 20.7 Induced pluripotent stem cells (iPSCs)
- 20.8 Conclusion: future directions for lung stem cells through bioengineered lung tissue
- 20.9 Acknowledgments
- Chapter 21: Genitourinary progenitor and stem cell biology and therapy
-
Chapter 11: Adipose tissue-derived stem cell biology and therapy
- Index
Product information
- Title: Progenitor and Stem Cell Technologies and Therapies
- Author(s):
- Release date: March 2012
- Publisher(s): Woodhead Publishing
- ISBN: 9780857096074
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