Olfactory mucosa: neural stem and progenitor cells for nervous system repair and cell models of brain disease
A. Mackay-Sim, Griffith University, Australia
Within the sensory organ of smell is a multipotent stem cell that is responsible for the normal regeneration and repair of the olfactory epithelium throughout life. This tissue is readily accessible without adverse outcome and the olfactory stem cells and neural progenitors can be grown from all adults. Olfactory stem cells and olfactory ensheathing cells (the glia from the olfactory nerve) are therapeutic when transplanted into animal models of brain injury and disease. A Phase I clinical trial of olfactory ensheathing cells in human spinal cord injury showed that they ...