Progenitor and stem cell therapies for cartilage repair

S. Saha, J. Kirkham, D.J. Wood and X.B. Yang,     University of Leeds, UK


Cell-based therapies and tissue engineering strategies offer new approaches for repair of degenerate/damaged articular cartilage. This chapter provides a brief overview of the clinical need for cartilage repair, the current clinical treatment options and their limitations, and then discusses the chondrogenic potential of different cell sources including embryonic stem cells, stem cells derived from prenatal tissues and adult mesenchymal stem cells. It also addresses the role of chondroprogenitor cells along with the advent of induced pluripotent stem cells in cartilage regeneration, and follows this ...

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