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Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases
book

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases

by Honghui Zhou, Diane R. Mould
March 2019
Intermediate to advanced content levelIntermediate to advanced
496 pages
15h
English
Wiley
Content preview from Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases

10Application of Pharmacometrics and Systems Pharmacology to Current and Emerging Biologics in Inflammatory Bowel Diseases

Sihem Ait‐Oudhia Yi Ting (Kayla) Lien Sumit Basu Lawrence Lesko and Stephan Schmidt

University of Florida, Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, Orlando, FL, USA

10.1 Introduction

Inflammatory bowel diseases (IBDs) represent a group of intestinal disorders. Together, they are the third highest risk factor for colorectal cancer [14]. In the United States, IBDs affect approximately 1.3 million people. The majority of patients is between 15 and 30 years old [5,6]. IBDs are complex disorders, which evolve through several convoluted immunological pathways. They are characterized by processes of remission and relapse, which ultimately result in functional impairment of the gut wall. IBDs are typically classified into two major types: ulcerative colitis (UC) and Crohn's disease (CD). This classification is essentially based on the location of the inflammation in the gastrointestinal tract (GIT) [7,8]. The Center for Disease Control and Prevention defines IBD as “a broad term that describes conditions characterized by chronic inflammation of the GIT with the two most common IBD being UC and CD.” Currently, there is no gold standard criteria for the diagnosis of IBD neither for distinguishing between UC and CD [913]. For example, one way to decipher UC from CD is through examination of their distinct ...

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Publisher Resources

ISBN: 9781119289197Purchase book