Regenerative Dentistry

Book description

Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment.

In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex.

The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented.

Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry.

Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry

Table of contents

  1. Preface
  2. Introduction to Regenerative Dentistry
    1. Chapter Summary
    2. Materials Used in Dental Tissue Regeneration
      1. Materials Used for Tooth Regeneration
      2. Bone
      3. Temporo-Mandibular Joint (TMJ)
    3. Protein, Gene, and Other Molecule Delivery Systems
      1. Protein Delivery
      2. Gene Delivery
      3. Delivery of Other Molecules
    4. Cellular Therapies for Dental Tissue Engineering
      1. Stem Cell Isolation
      2. Dental Pulp Stem Cells
      3. Periodontal Ligament Stem Cells
      4. Salivary Gland Stem Cells
      5. Bone Marrow Stromal Cells
    5. Bibliography
  3. Tissue Engineering Alveolar Bone
    1. Chapter Summary
    2. Tissue Engineering Alveolar Bone
      1. Introduction
      2. Macroscopic Features of Alveolar Bone
      3. Microscopic Features of Alveolar Bone
      4. Mineralization of Alveolar Bone
      5. Alveolar Bone Functions
    3. The Problem of Alveolar Bone Resorption
    4. Alveolar Bone Regeneration: Conventional and Current Therapy
    5. Alveolar Extraction Socket: A Model for Alveolar Bone Wound Healing
    6. Tissue Engineering Alveolar Bone
      1. Cellular Key-Players in Alveolar Bone Engineering
      2. Growth Factors for Alveolar Bone Engineering: Intrinsic Signals for Bone Development and Repair (1/2)
      3. Growth Factors for Alveolar Bone Engineering: Intrinsic Signals for Bone Development and Repair (2/2)
      4. The Scaffold: The Engineered Guided Tissue Mimetic
    7. Current Promising Application (1/2)
    8. Current Promising Application (2/2)
    9. Acknowledgments
    10. Bibliography
  4. Tissue Engineering of the Periodontal Tissues
    1. Chapter Summary
    2. Introduction: The Induction of Bone Formation
    3. Dissociative Extraction and Reconstitution of the Bone Matrix Components: Restoration of the Endochondral Bone Induction Cascade
    4. Naturally-Derived Bone Morphogenetic Proteins Induce Cementogenesis and the Induction of Periodontal Ligament Regeneration
    5. Redundancy and Structure/Activity Profile of the Osteogenic Proteins of the Transforming Growth Factor- Supergene Family
    6. Challenges: Stem Cells, Riding Cells and the Synergistic Induction of Bone Formation
    7. Acknowledgments
    8. Bibliography
  5. Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry
    1. Chapter Summary
    2. Introduction
    3. Dynamics for Pulp/Dentin Tissue Engineering in Operative Dentistry
      1. Pulp/Dentin Complex in Health
      2. Pulp/Dentin Complex in Disease
    4. Regeneration of Pulp/Dentin-Like Structures: Experimental Models and Mechanisms
      1. Experimental Ex Vivo Models
      2. Experimental in Vivo Models (1/2)
      3. Experimental in Vivo Models (2/2)
    5. Design Principles in the Regenerative Treatment Strategies of Pulp/Dentin Complex
      1. The Restorative vs Regenerative Concept in Operative Dentistry
      2. Improving Dentinal Reactions in Non-Exposed Cavities (Non-Exposed Dentinal Cavity Situation)
      3. Developing Dentin-Like Structures in Pulp Exposures (Pulp Capping Situation)
      4. Engineering Dental Pulp in Immature Teeth (Pulpless Immature Tooth Apex Situation)
      5. Bibliography (1/5)
      6. Bibliography (2/5)
      7. Bibliography (3/5)
      8. Bibliography (4/5)
      9. Bibliography (5/5)
  6. Authors' Biographies (1/2)
  7. Authors' Biographies (2/2)

Product information

  • Title: Regenerative Dentistry
  • Author(s): Mona Marei
  • Release date: June 2010
  • Publisher(s): Morgan & Claypool Publishers
  • ISBN: 9781608452149