
Accurate sample size calculation ensures that clinical studies have
adequate power to detect clinically meaningful effects. This results in
the efcient use of resources and avoids exposing a disproportionate
number of patients to experimental treatments caused by an over-
powered study.
Sample Size Calculations for Clustered and Longitudinal Out-
comes in Clinical Research explains how to determine sample size
for studies with correlated outcomes, which are widely implemented
in medical, epidemiological, and behavioral studies.
The book focuses on issues specic to the two types of correlated
outcomes: longitudinal and clustered. For cluster