
3
Sample Size Determination for Repeated
Measurement Outcomes Using Summary
Statistics
3.1 Introduction
A repeated measures design deals with response outcomes measured on the
same experimental unit at different times or under different conditions. Re-
peated measurements can refer to multiple measurements on an experimental
unit, such as the measurements of thickness of skin in arms, hands, fingers,
face, neck, and trunk of scleroderma patients. Repeated measurements can
be taken over a period of time, such as daily measurements of blood glucose
levels or weekly measurements of systolic blood pressures or weights. The
repeated assessments might be measured ...