
Sample Size Determination for Repeated Measurement Outcomes 71
the inverse of the within–subject correlation matrix of the repeated measure-
ments.
Chapter 4 includes additional discussion of sample size approaches for
the comparisons of rates of change under various correlation structures, and
missing data patterns. Chapter 5 also includes additional discussion of sample
size approaches for the comparisons of rates of change in two–level longitudinal
designs under the assumption of a fixed slope and a random slope.
3.3.4 Difference in Rate of Change across Time with Baseline
Covariate
The linear trend scores are not generally independent of baseline