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Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
book

Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

by Chul Ahn, Moonseoung Heo, Song Zhang
December 2014
Intermediate to advanced content levelIntermediate to advanced
260 pages
8h 51m
English
Chapman and Hall/CRC
Content preview from Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
76 Sample Size Calculations for Clustered and Longitudinal Outcomes
3.3.7 Sample Size Estimation under Financial Constraints
In clinical trials, sample size is generally estimated based on the number of
subjects necessary to detect clinically meaningful differences between treat-
ment groups. However, budget constraint is a challenge faced by investigators
in planning almost every clinical trial. Sample size needs to be estimated by
incorporating costs for recruiting and measuring subjects in repeated mea-
surement studies [23, 24, 25, 26, 27].
Lai et al. [23] investigated how to determine the optimal number of subjects
and number of measurements per ...
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Publisher Resources

ISBN: 9781466556270