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Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
book

Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

by Chul Ahn, Moonseoung Heo, Song Zhang
December 2014
Intermediate to advanced content levelIntermediate to advanced
260 pages
8h 51m
English
Chapman and Hall/CRC
Content preview from Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
138 Sample Size Calculations for Clustered and Longitudinal Outcomes
calculation for multi-level clustered trial using linear mixed models can be
found in Heo and Leon [74].
A potential future development of GEE sample size calculation is the re-
estimation of variance matrix and subsequently, the sample size, based on
interim data. The estimation of sample size in clinical trials requires knowl-
edge of parameters that involve treatment effect, variability, and correlation
(for clustered/longitudinal measurements), which are usually uncertain to re-
searchers at the design stage. This uncertainty is especially pronounced for
clinical trials with new ...
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Publisher Resources

ISBN: 9781466556270