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Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
book

Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

by Chul Ahn, Moonseoung Heo, Song Zhang
December 2014
Intermediate to advanced content levelIntermediate to advanced
260 pages
8h 51m
English
Chapman and Hall/CRC
Content preview from Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
174 Sample Size Calculations for Clustered and Longitudinal Outcomes
Time from baseline T
k
0 1 2 T
end
=(N
1
–1)
δ
XZT
T
end
X=0, Z=0
X=0, Z=1
X=1, Z=0
X=1, Z=1
η
00
η
01
η
10
η
11
= S
11
+
δ
XZT
S
11
FIGURE 5.2
Geometrical representations of fixed parameters in model (5.31) for a 2-by-2
factorial longitudinal cluster randomized trial.
Note: η
00
= δ
T
; η
01
= η
00
+δ
ZT
= δ
T
+δ
ZT
η
10
= η
00
+δ
XT
= δ
T
+δ
XT
; S
11
=
η
00
+ δ
XT
+ δ
ZT
= δ
T
+ δ
XT
+ δ
ZT
represents a hypothetical slope for the
(X = 1, Z = 1) arm under the null hypothesis H
0
: δ
XZT
= 0 in model (5.31);
and η
11
= η
00
+ δ
XT
+ δ
ZT
+ δ
XZT
= S
11
+ δ
XZT
.
2 units. In a balanced design, the sample sizes of the other cells are identical
to N
(1,1)
2
, i.e., ...
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Publisher Resources

ISBN: 9781466556270