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Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
book

Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

by Chul Ahn, Moonseoung Heo, Song Zhang
December 2014
Intermediate to advanced content levelIntermediate to advanced
260 pages
8h 51m
English
Chapman and Hall/CRC
Content preview from Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
6
Sample Size Determination for Correlated
Outcomes from Three-Level Randomized
Clinical Trials
6.1 Introduction
We now consider sample size approaches for randomized clinical trials with
a three-level data structure. One example of a study with this structure is a
large scale randomized trial to test a behavioral intervention to increase phys-
ical activity in school age children. In this design, students (level 1) are nested
within classrooms (level 2) which are nested within schools (level 3). A second
example is a longitudinal study of patients from multiple clinics in which the
repeated measures comprise the first level, patients are the second lev ...
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Publisher Resources

ISBN: 9781466556270